100 Binney St. Cambridge. Image courtesy of Elkus Manfredi Arcitects

Facebook is considering its largest expansion in Massachusetts since arriving in Cambridge’s Kendall Square in 2013, as it scouts potential locations for up to 350,000 square feet of additional space.

Facebook’s new requirement is among the three largest in the Boston office market, according to a report released this week by Colliers International. Financial service firms Eaton Vance and Loomis Sayles & Co. also have been in the market for more than 300,000 square feet since 2019.

The social media giant’s search for more space for comes despite the transformation of corporate work during the COVID-19 pandemic. Facebook and other leading tech firms have transitioned to work-from-home policies and told employees they’re free to avoid the office on a long-term basis. In a May video stream, CEO Mark Zuckerberg estimated that half of the company’s 45,000 employees could be working remotely in the future.

The company has been operating its office buildings at 25 percent capacity during the pandemic.

Facebook’s presence in Cambridge dates back to 2013, when it first leased a small office at One Broadway. In 2017, it snapped up 130,000 square feet at 100 Binney St., a speculative office-lab building developed by Alexandria Real Estate Equities.

A message seeking comment was not immediately returned by Facebook.

Large blocks of office space continue to be scarce in the near term in East Cambridge, where the vacancy rate stood at just under 2 percent at the end of the first quarter, according to CBRE data.

But one new option materialized in the second quarter as Bluebird Bio offered its 250,000-square-foot space at 50 Binney St. for sublease, according to local brokerages. The biotech firm is seeking approximately $100 per square foot on a triple-net basis for the space, which it subleased from Sanofi in early 2019.